O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)
نویسندگان
چکیده
منابع مشابه
AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production
Soluble oligomeric amyloid β peptide (Aβ) generated from processing of the amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's Disease (AD) and through actions at glutamatergic synapses affects excitability and plasticity. The physiological control of APP processing is not fully understood but stimulation of synaptic NMDA receptors (NMDAR) can suppress Aβ lev...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2013
ISSN: 1750-1326
DOI: 10.1186/1750-1326-8-s1-p21